Endocrine Abstracts

Introduction: Vitamin D has pleiotropic effect on human body. Several studies showed that vitamin D deficiency has an influence on inflammation status in endocrine diseases (PCO-S, Graves disease, autoimmune endocrine disorders) and could reflect body fat tissue contain. Both, resistin and leptin, show pro-inflammatory effect.Aim: The aim of the study was to asses resistin and leptin serum concentration and its relationship with 25-OH vitamin D concentra...

Introduction: Cushing disease, as a state of chronic hypercortisolism, causes diverse, often nonspecific symptoms, possibly delaying the proper diagnosis.Case report: A 59-year-old woman with the history of type 2 diabetes mellitus, hypertension, osteoporosis and multiannual history of recurrent hospitalizations because of life-threatening multi-sited soft tissue and muscle abscesses, was admitted to the Department of Internal Medicine and Metabolic Dise...

Introduction: Visfatin is a protein secreted by adipose tissue which was discovered as a protein with insulin-mimetic properties. Experimental and clinical studies demonstrated that visfatin can be involved in the pathogenesis of insulin resistance. It was demonstrated that plasma visfatin is elevated in insulin resistant states i.e. obesity, type two diabetes mellitus, PCOS. In vitro study showed that insulin inhibits visfatin release from adipocytes. The aim of the pr...

Introduction: CHEK2 is a gene encoding a protein involved in the mechanism of repairing damaged DNA. Mutations in the CHEK2 gene are associated with an increased risk of various neoplasms. The most common mutations in the Polish population are: I157T, less frequently IVS2+1G> A and 1100delC.Materials: The study consisted of 277 patients with papillary thyroid carcinoma: 252 female, 25 male, aged 15 to 76 years.Method: Patients ...

Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL-12 is a proinflammatory cytokine with proatherogenic properties. IL-12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL-12. The aim of the present study was to estimate serum IL-12 and p40 subunit in ...

Introduction: Diagnosis of pheochromocytoma is rarely established in pregnancy, although can cause threat to health and life of foetus and mother. Exact and early diagnosis is crucial for effective treatment.Purpose: The purpose of our study is to present a case of patient with pheochromocytoma and medullary thyroid carcinoma (MCT) – MEN2A syndrome - diagnosed in 9-th week of pregnancy.Material and method: Twenty nine-year-old...

Polycystic ovary syndrome (PCOS) is heterogeneous disorder leading to infertility. The introduction of Rotterdam criteria creates different PCOS phenotypes, i.e. hyperandrogenic anovulatory with (A) and without (B) polycystic ovaries (PCO) morphology in ultrasonography (usg), hyperandrogenic ovulatory with PCO morphology in usg (C), non-hyperandrogenic anovulatory with PCO morphology in usg (D). In PCOS insulin resistance might be involved in the development of endocrine and m...

Fibroblast growth factor 21 (FGF21) might increase glucose uptake in adipocytes and reduce plasma glucose and triglycerides in animal models of diabetes. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation. We examined 76 subjects with normal glucose tolerance, 36 lean (BMI <25 kg/m2) and 39 overweight or obese...

Polycystic ovary syndrome (PCOS) is a main cause of women infertility. There are data suggesting an increased risk for cardiovascular disease in PCOS. Insulin resistance might play a role in the pathogenesis of PCOS and its metabolic complications. The aim of the study was to asses the prevalence of The National Cholesterol Education Program (NCEP)-defined metabolic syndrome (MS) in women with PCOS in relation to insulin resistance and endothelial dysfunction – soluble E-...

Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight. In AN, similarly to syndromes of lipodystrophy, one observes the significant loss of the adipose tissue. In lipodystrophies, despite the lack of subcutaneous adipose tissue, insulin resistance is observed. Adipose tissue is known as a source of a variety of bioactive peptides, known as adipocytokines. The aim of the present study was to examine the plasma concentration of adipocytokines in relation...